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Mouse Anti-GLRX2 Recombinant Antibody (CBFYH-0392) (CBMAB-H1263-FY)

This product is mouse antibody that recognizes GLRX2. The antibody CBFYH-0392 can be used for immunoassay techniques such as: IP.
See all GLRX2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0392
Antibody Isotype
IgG2a, κ
Application
IP

Basic Information

Immunogen
Recombinant human protein purified from E.coli
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
glutaredoxin 2
Introduction
The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression.
Entrez Gene ID
51022
UniProt ID
Q9NS18
Alternative Names
Glutaredoxin 2; Glutaredoxin (Thioltransferase) 2; GRX2; BA101E13.1 (GRX2 Glutaredoxin (Thioltransferase) 2); CGI-133
Function
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Biological Process
Aging Source: Ensembl
Apoptotic process Source: UniProtKB
Cell differentiation Source: UniProtKB
Cell redox homeostasis Source: UniProtKB
Cellular response to superoxide Source: Ensembl
DNA protection Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Regulation of signal transduction Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Response to hydrogen peroxide Source: UniProtKB
Response to organic substance Source: UniProtKB
Response to redox state Source: UniProtKB
Response to temperature stimulus Source: UniProtKB
Cellular Location
Isoform 1: Mitochondrion
Isoform 2: Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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