Mouse Anti-GLRX2 Recombinant Antibody (CBLG1-129) (CBMAB-G0528-LY)

Name: Mouse Anti-GLRX2 Recombinant Antibody (CBLG1-129)
SKU: CBMAB-G0528-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBLG1-129

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glutaredoxin 2

Introduction

The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]

Entrez Gene ID

51022

UniProt ID

Q9NS18

Alternative Names

Glutaredoxin 2; Glutaredoxin (Thioltransferase) 2; GRX2; BA101E13.1 (GRX2 Glutaredoxin (Thioltransferase) 2); CGI-133;

Function

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Biological Process

Aging Source: Ensembl
Apoptotic process Source: UniProtKB
Cell differentiation Source: UniProtKB
Cell redox homeostasis Source: UniProtKB
Cellular response to superoxide Source: Ensembl
DNA protection Source: UniProtKB
Glutathione metabolic process Source: UniProtKB
Regulation of signal transduction Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Response to hydrogen peroxide Source: UniProtKB
Response to organic substance Source: UniProtKB
Response to redox state Source: UniProtKB
Response to temperature stimulus Source: UniProtKB

Cellular Location

Isoform 1: Mitochondrion
Isoform 2: Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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