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Rabbit Anti-GRIN2C Recombinant Antibody (CBWJN-1109) (CBMAB-N0865-WJ)

This product is a Rabbit antibody that recognizes GRIN2C. The antibody CBWJN-1109 can be used for immunoassay techniques such as: WB.
See all GRIN2C antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBWJN-1109
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutamate Ionotropic Receptor NMDA Type Subunit 2C
Introduction
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Entrez Gene ID
Human2905
Mouse14813
Rat24411
UniProt ID
HumanQ14957
MouseQ01098
RatQ00961
Alternative Names
Glutamate Ionotropic Receptor NMDA Type Subunit 2C; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2C; Glutamate [NMDA] Receptor Subunit Epsilon-3; N-Methyl D-Aspartate Receptor Subtype 2C; NMDAR2C; GluN2C; NR2C; N-Methyl-D-Aspartate Receptor Subunit 2C; Glutamate Receptor Ionotropic, NMDA 2C;
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626).

Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Biological Process
Brain development Source: ARUK-UCL
Calcium ion transmembrane import into cytosol Source: UniProtKB
Directional locomotion Source: Ensembl
Excitatory chemical synaptic transmission Source: ARUK-UCL
Excitatory postsynaptic potential Source: GO_Central
Glutamate receptor signaling pathway Source: ProtInc
Long-term synaptic potentiation Source: GO_Central
Negative regulation of protein catabolic process Source: Ensembl
Neuromuscular process controlling balance Source: Ensembl
Protein localization to postsynaptic membrane Source: Ensembl
Regulation of synaptic plasticity Source: ARUK-UCL
Response to wounding Source: Ensembl
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 20-554
Helical: 555-573
Cytoplasmic: 574-600
Discontinuously helical: 601-620
Cytoplasmic: 621-627
Helical: 628-643
Extracellular: 644-814
Helical: 815-834
Cytoplasmic: 835-1233
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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