Mouse Anti-GRIN2C Recombinant Antibody (CBWJN-1109) (CBMAB-N0865-WJ)

Name: Mouse Anti-GRIN2C Recombinant Antibody (CBWJN-1109)
SKU: CBMAB-N0865-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBWJN-1109

Application

WB, IF, IHC, WB

Immunogen

Fusion protein amino acids 836-1233 (C-terminus) of rat GluN2C.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Tris

Preservative

Sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Glutamate Ionotropic Receptor NMDA Type Subunit 2C

Introduction

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Entrez Gene ID

Human	2905
Mouse	14813
Rat	24411

UniProt ID

Human	Q14957
Mouse	Q01098
Rat	Q00961

Alternative Names

Glutamate Ionotropic Receptor NMDA Type Subunit 2C; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2C; Glutamate [NMDA] Receptor Subunit Epsilon-3; N-Methyl D-Aspartate Receptor Subtype 2C; NMDAR2C; GluN2C; NR2C; N-Methyl-D-Aspartate Receptor Subunit 2C; Glutamate Receptor Ionotropic, NMDA 2C;

Function

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626).

Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).

Biological Process

Brain development Source: ARUK-UCL
Calcium ion transmembrane import into cytosol Source: UniProtKB
Directional locomotion Source: Ensembl
Excitatory chemical synaptic transmission Source: ARUK-UCL
Excitatory postsynaptic potential Source: GO_Central
Glutamate receptor signaling pathway Source: ProtInc
Long-term synaptic potentiation Source: GO_Central
Negative regulation of protein catabolic process Source: Ensembl
Neuromuscular process controlling balance Source: Ensembl
Protein localization to postsynaptic membrane Source: Ensembl
Regulation of synaptic plasticity Source: ARUK-UCL
Response to wounding Source: Ensembl

Cellular Location

Cell membrane; Postsynaptic cell membrane

Topology

Extracellular: 20-554
Helical: 555-573
Cytoplasmic: 574-600
Discontinuously helical: 601-620
Cytoplasmic: 621-627
Helical: 628-643
Extracellular: 644-814
Helical: 815-834
Cytoplasmic: 835-1233

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GRIN2C Matched Antibody Pair (500) (CAT#: APMAB-500LY)

Related Products

Mouse Anti-GRIN2C Monoclonal Antibody (1425) (CAT#: V2LY-0226-LY1277)

GRIN2C Matched Antibody Pair (500) (CAT#: APMAB-500LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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