Mouse Anti-GRIN2C Monoclonal Antibody (1425) (V2LY-0226-LY1277)

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Basic Information

Host Animal
Mouse
Clone
1425
Application
WB, IF, IHC
Immunogen
Fusion protein (aa 836-1233)
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Glutamate Ionotropic Receptor NMDA Type Subunit 2C
Entrez Gene ID
Human2905
Mouse14813
Rat24411
UniProt ID
HumanQ14957
MouseQ01098
RatQ00961
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:26875626).

Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Biological Process
Brain development Source: ARUK-UCL
Calcium ion transmembrane import into cytosol Source: UniProtKB
Directional locomotion Source: Ensembl
Excitatory chemical synaptic transmission Source: ARUK-UCL
Excitatory postsynaptic potential Source: GO_Central
Glutamate receptor signaling pathway Source: ProtInc
Long-term synaptic potentiation Source: GO_Central
Negative regulation of protein catabolic process Source: Ensembl
Neuromuscular process controlling balance Source: Ensembl
Protein localization to postsynaptic membrane Source: Ensembl
Regulation of synaptic plasticity Source: ARUK-UCL
Response to wounding Source: Ensembl
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 20-554
Helical: 555-573
Cytoplasmic: 574-600
Discontinuously helical: 601-620
Cytoplasmic: 621-627
Helical: 628-643
Extracellular: 644-814
Helical: 815-834
Cytoplasmic: 835-1233
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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