Mouse Anti-NFIC Recombinant Antibody (A1337) (CBMAB-AP5087LY)

Name: Mouse Anti-NFIC Recombinant Antibody (A1337)
SKU: CBMAB-AP5087LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A1337

Application

ICC, WB

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Nuclear Factor I C

Introduction

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Entrez Gene ID

4782

UniProt ID

P08651

Alternative Names

Nuclear Factor I C; Nuclear Factor I/C (CCAAT-Binding Transcription Factor); CCAAT-Box-Binding Transcription Factor; TGGCA-Binding Protein; NF-I/C; NF1-C; CTF; NFI;

Function

SAB-27175

Biological Process

DNA replicationIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus

Wu, J., Wang, M., Zhang, Y., Liu, G., & Xing, Y. (2024). Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer. Functional & Integrative Genomics, 24(1), 1-13.

Rastogi, N., Gonzalez, J. B. M., Srivastava, V. K., Alanazi, B., Alanazi, R. N., Hughes, O. M., ... & Tonks, A. (2023). Nuclear factor IC overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia, 37(2), 276-287.

Shukla, V., Wang, H., Varticovski, L., Baek, S., Wang, R., Echtenkamp, F. J., ... & Schrump, D. S. (2023). MA09. 04 Genome-wide Analysis Identifies Nuclear Factor IC as a Novel Transcription Factor and Potential Therapeutic Target in SCLC. Journal of Thoracic Oncology, 18(11), S129-S130.

Cobo, I., Paliwal, S., Bodas, C., Felipe, I., Melià-Alomà, J., Torres, A., ... & Real, F. X. (2023). NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nature Communications, 14(1), 3761.

Xu, C., Xie, X., Zhao, L., Wu, Y., & Wang, J. (2022). The critical role of nuclear factor I‐C in tooth development. Oral Diseases, 28(8), 2093-2099.

Lee, D. S., Song, Y. J., Gug, H. R., Lee, J. H., Bae, H. S., & Park, J. C. (2022). Nuclear Factor IC Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells. Stem Cells International, 2022.

Zhang, H., Luo, Z., Tang, J., Tian, J., Xiao, Y., Sun, C., & Wang, T. (2022). Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2. Cell Cycle, 21(1), 63-73.

Huang, W., Huang, T., Liu, Y., Fu, J., Wei, X., Liu, D., ... & Yuan, Z. (2021). Nuclear factor IC disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Cell death & disease, 13(1), 17.

Lee, D. S., Roh, S. Y., Choi, H., & Park, J. C. (2020). NFI-C is required for epiphyseal chondrocyte proliferation during postnatal cartilage development. Molecules and Cells, 43(8), 739.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

NFIC Matched Antibody Pair (794) (CAT#: APMAB-794LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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