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Mouse Anti-NFIC Recombinant Antibody (A1338) (CBMAB-AP12624LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A1338
Antibody Isotype
IgG
Application
ICC, WB

Basic Information

Immunogen
Purified recombinant human NFIC protein fragments expressed in Ecoli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nuclear Factor I C
Introduction
The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Entrez Gene ID
4782
UniProt ID
P08651
Alternative Names
Nuclear Factor I C; Nuclear Factor I/C (CCAAT-Binding Transcription Factor); CCAAT-Box-Binding Transcription Factor; TGGCA-Binding Protein; NF-I/C; NF1-C; CTF; NFI;
Function
Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Biological Process
DNA replicationIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
More Infomation

Wu, J., Wang, M., Zhang, Y., Liu, G., & Xing, Y. (2024). Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer. Functional & Integrative Genomics, 24(1), 1-13.

Rastogi, N., Gonzalez, J. B. M., Srivastava, V. K., Alanazi, B., Alanazi, R. N., Hughes, O. M., ... & Tonks, A. (2023). Nuclear factor IC overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia, 37(2), 276-287.

Shukla, V., Wang, H., Varticovski, L., Baek, S., Wang, R., Echtenkamp, F. J., ... & Schrump, D. S. (2023). MA09. 04 Genome-wide Analysis Identifies Nuclear Factor IC as a Novel Transcription Factor and Potential Therapeutic Target in SCLC. Journal of Thoracic Oncology, 18(11), S129-S130.

Cobo, I., Paliwal, S., Bodas, C., Felipe, I., Melià-Alomà, J., Torres, A., ... & Real, F. X. (2023). NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nature Communications, 14(1), 3761.

Xu, C., Xie, X., Zhao, L., Wu, Y., & Wang, J. (2022). The critical role of nuclear factor I‐C in tooth development. Oral Diseases, 28(8), 2093-2099.

Lee, D. S., Song, Y. J., Gug, H. R., Lee, J. H., Bae, H. S., & Park, J. C. (2022). Nuclear Factor IC Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells. Stem Cells International, 2022.

Zhang, H., Luo, Z., Tang, J., Tian, J., Xiao, Y., Sun, C., & Wang, T. (2022). Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2. Cell Cycle, 21(1), 63-73.

Huang, W., Huang, T., Liu, Y., Fu, J., Wei, X., Liu, D., ... & Yuan, Z. (2021). Nuclear factor IC disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Cell death & disease, 13(1), 17.

Lee, D. S., Roh, S. Y., Choi, H., & Park, J. C. (2020). NFI-C is required for epiphyseal chondrocyte proliferation during postnatal cartilage development. Molecules and Cells, 43(8), 739.

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For research use only. Not intended for any clinical use.

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