NFIC

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Full Name

Nuclear Factor I C

Function

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Biological Process

DNA replicationIEA:UniProtKB-KW
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus

Anti-NFIC antibodies

Mouse Anti-NFIC Recombinant Antibody (CBWJN-1373) (CBMAB-N2230-WJ)

Datasheet

SDS

Target: NFIC

Host: Mouse

Specificity: Human

Clone: CBWJN-1373

Application*: WB

Mouse Anti-NFIC Recombinant Antibody (CBWJN-0415) (CBMAB-N2229-WJ)

Datasheet

SDS

Target: NFIC

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse, Rat, Chicken, Cattle, Human, Pig

Clone: CBWJN-0415

Application*: WB, IC

Mouse Anti-NFIC Recombinant Antibody (2C3) (CBMAB-N2228-WJ)

Datasheet

SDS

Target: NFIC

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2C3

Application*: E, WB

Mouse Anti-NFIC Recombinant Antibody (1C12-2A2) (CBMAB-N2226-WJ)

Datasheet

SDS

Target: NFIC

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C12-2A2

Application*: E, IF, IH, WB

Datasheet

SDS

Target: NFIC

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)