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Recombinant Rabbit Anti-PIK3R3 Antibody (CBAb189) (CBMAB-Ab189-LY)

The product is antibody recognizes PIK3R3. The antibody CBAb189 immunoassay techniques such as: WB 1:500-1:1000; IHC 1:50-1:200; IF 1:50-1:200.
See all PIK3R3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBAb189
Antibody Isotype
IgG
Application
WB 1:500-1:1000; IHC 1:50-1:200; IF 1:50-1:200

Basic Information

Immunogen
Recombinant protein of human PIK3R3
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphoinositide-3-kinase regulatory subunit 3
Introduction
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.
Entrez Gene ID
Human8503
Mouse18710
Rat60664
UniProt ID
HumanQ92569
MouseQ64143
RatQ63789
Alternative Names
PIK3R3; p55; p55-GAMMA; p55PIK; phosphoinositide-3-kinase regulatory subunit 3
Function
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Biological Process
B cell differentiation1 PublicationIC:ComplexPortal
Cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Immune response1 PublicationIC:ComplexPortal
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of anoikis1 PublicationIC:ComplexPortal
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell migration1 PublicationNAS:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Protein kinase B signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIBA:GO_Central
T cell differentiation1 PublicationIC:ComplexPortal
Cellular Location
cytosol
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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