PIK3R3

Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.

Full Name

phosphoinositide-3-kinase regulatory subunit 3

Function

Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

Biological Process

B cell differentiation1 PublicationIC:ComplexPortal
Cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Immune response1 PublicationIC:ComplexPortal
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of anoikis1 PublicationIC:ComplexPortal
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell migration1 PublicationNAS:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Protein kinase B signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIBA:GO_Central
T cell differentiation1 PublicationIC:ComplexPortal

Cellular Location

cytosol
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA