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Rabbit Anti-PIK3R3 Recombinant Antibody (D2B3) (CBMAB-CP1962-LY)

The product is antibody recognizes PIK3R3. The antibody D2B3 immunoassay techniques such as: WB,IP.
See all PIK3R3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
D2B3
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PI3 kinase p55 protein.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphoinositide-3-kinase regulatory subunit 3
Introduction
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016]
Entrez Gene ID
Human8503
Mouse18710
UniProt ID
HumanQ92569
MouseQ64143
Alternative Names
Phosphoinositide-3-Kinase Regulatory Subunit 3; Phosphatidylinositol 3-Kinase 55 KDa Regulatory Subunit Gamma; Phosphoinositide-3-Kinase; Regulatory Subunit 3 (Gamma); PtdIns-3-Kinase Regulatory Subunit P55-Gamma; PI3-Kinase Regulatory Subunit Gamma; PI3K Regulatory Subunit Gamma; PI3-Kinase Subunit P55-Gamma; P55PIK;
Function
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Biological Process
B cell differentiation1 PublicationIC:ComplexPortal
Cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Immune response1 PublicationIC:ComplexPortal
Insulin receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of anoikis1 PublicationIC:ComplexPortal
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell migration1 PublicationNAS:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Protein kinase B signalingManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of phosphatidylinositol 3-kinase activityManual Assertion Based On ExperimentIBA:GO_Central
T cell differentiation1 PublicationIC:ComplexPortal
Cellular Location
cytosol
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase complex, class IA
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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