ADGRL1

ADGRL1 is a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich G

Full Name

Adhesion G Protein-Coupled Receptor L1

Function

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Calcium-mediated signaling using intracellular calcium
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Positive regulation of synapse maturation

Cellular Location

Cell membrane; Presynaptic cell membrane; Axon; Growth cone; Synapse; Synaptosome. Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.

Topology

Extracellular: 25-858 aa
Helical: 859-879 aa
Cytoplasmic: 880-893 aa
Helical: 894-914 aa
Extracellular: 915-920 aa
Helical: 921-941 aa
Cytoplasmic: 942-964 aa
Helical: 965-985 aa
Extracellular: 986-1002 aa
Helical: 1003-1023 aa
Cytoplasmic: 1024-1050 aa
Helical: 1051-1071 aa
Extracellular: 1072-1075 aa
Helical: 1076-1096 aa
Cytoplasmic: 1097-1474 aa

PTM

Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus (By similarity).