BBC3

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Full Name

BCL2 Binding Component 3

Function

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391).
Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338).

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: UniProtKB
Cellular response to DNA damage stimulus Source: BHF-UCL
Cellular response to hypoxia Source: UniProtKB
Determination of adult lifespan Source: BHF-UCL
Execution phase of apoptosis Source: UniProtKB
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum calcium ion concentration Source: UniProtKB
Negative regulation of growth Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity Source: UniProtKB
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Positive regulation of neuron apoptotic process Source: UniProtKB
Positive regulation of protein-containing complex assembly Source: UniProtKB
Positive regulation of protein homooligomerization Source: UniProtKB
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: UniProtKB
Positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Positive regulation of thymocyte apoptotic process Source: BHF-UCL
Protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
Regulation of apoptotic process Source: Reactome
Release of cytochrome c from mitochondria Source: UniProtKB
Release of sequestered calcium ion into cytosol Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB

Cellular Location

Mitochondrion. Localized to the mitochondria in order to induce cytochrome c release.