CCDC25

CCDC25 (Coiled-Coil Domain Containing 25) is a Protein Coding gene.

Full Name

Coiled-Coil Domain Containing 25

Function

Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174).
NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174).
Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174).
Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174).
In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174).

Biological Process

Positive regulation of cell motility Source: UniProtKB

Cellular Location

Cell membrane; Endomembrane system. Localizes to cytoplasmic membrane in tumor cells.

Topology

Extracellular: 1-66
Helical: 67-83
Cytoplasmic: 84-208