CCL3

CCL3 (C-C Motif Chemokine Ligand 3) is a Protein Coding gene. Diseases associated with CCL3 include Human Immunodeficiency Virus Type 1 and Chagas Disease. Among its related pathways are PEDF Induced Signaling and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and kinase activity. An important paralog of this gene is CCL3L3.

C-C Motif Chemokine Ligand 3

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).

Astrocyte cell migration Source: UniProtKB
Calcium ion transport Source: UniProtKB
Calcium-mediated signaling Source: UniProtKB
Cell activation Source: UniProtKB
Cell-cell signaling Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to organic cyclic compound Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
Eosinophil degranulation Source: UniProtKB
Exocytosis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Granulocyte chemotaxis Source: UniProtKB
Inflammatory response Source: UniProtKB
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Lymphocyte chemotaxis Source: UniProtKB
Macrophage chemotaxis Source: UniProtKB
MAPK cascade Source: UniProtKB
Monocyte chemotaxis Source: UniProtKB
Negative regulation by host of viral transcription Source: UniProtKB
Negative regulation of bone mineralization Source: UniProtKB
Negative regulation of gene expression Source: UniProtKB
Negative regulation of osteoclast differentiation Source: UniProtKB
Neutrophil chemotaxis Source: UniProtKB
Osteoblast differentiation Source: UniProtKB
Positive regulation of calcium ion import Source: BHF-UCL
Positive regulation of calcium ion transport Source: UniProtKB
Positive regulation of calcium-mediated signaling Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of inflammatory response Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of microglial cell activation Source: ARUK-UCL
Positive regulation of microglial cell migration Source: ARUK-UCL
Positive regulation of natural killer cell chemotaxis Source: UniProtKB
Positive regulation of neuron apoptotic process Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Positive regulation of tumor necrosis factor production Source: UniProtKB
Protein kinase B signaling Source: UniProtKB
Regulation of behavior Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Regulation of sensory perception of pain Source: UniProtKB
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: UniProtKB
Response to cholesterol Source: UniProtKB
Response to toxic substance Source: UniProtKB
Signaling Source: UniProtKB
T cell chemotaxis Source: UniProtKB

Secreted

N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.