CLDN5

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

claudin 5

Plays a major role in tight junction-specific obliteration of the intercellular space.

Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cell-cell junction assembly Source: UniProtKB
Establishment of blood-retinal barrier Source: ARUK-UCL
Face morphogenesis Source: UniProtKB
Learning Source: UniProtKB
Maintenance of blood-brain barrier Source: ARUK-UCL
Negative regulation of angiogenesis Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of vascular permeability Source: ARUK-UCL
Outflow tract morphogenesis Source: UniProtKB
Positive regulation of bicellular tight junction assembly Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of establishment of endothelial barrier Source: UniProtKB
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of protein binding Source: ARUK-UCL
Regulation of bicellular tight junction assembly Source: Reactome
Roof of mouth development Source: UniProtKB
Tight junction assembly Source: ARUK-UCL
Transforming growth factor beta receptor signaling pathway Source: UniProtKB

Cell membrane; Tight junction

Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-122
Helical: 123-143
Extracellular: 144-159
Helical: 160-180
Cytoplasmic: 181-218