CLDN5

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Full Name
claudin 5
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cell-cell junction assembly Source: UniProtKB
Establishment of blood-retinal barrier Source: ARUK-UCL
Face morphogenesis Source: UniProtKB
Learning Source: UniProtKB
Maintenance of blood-brain barrier Source: ARUK-UCL
Negative regulation of angiogenesis Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of gene expression Source: ARUK-UCL
Negative regulation of vascular permeability Source: ARUK-UCL
Outflow tract morphogenesis Source: UniProtKB
Positive regulation of bicellular tight junction assembly Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of establishment of endothelial barrier Source: UniProtKB
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of protein binding Source: ARUK-UCL
Regulation of bicellular tight junction assembly Source: Reactome
Roof of mouth development Source: UniProtKB
Tight junction assembly Source: ARUK-UCL
Transforming growth factor beta receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-122
Helical: 123-143
Extracellular: 144-159
Helical: 160-180
Cytoplasmic: 181-218
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Anti-CLDN5 antibodies

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Mouse Anti-CLDN5 Recombinant Antibody (CBCNC-011) (CBMAB-C0904-CN)

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Target: CLDN5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Monkey, Dog, Guinea pig, Human, Mouse, Pig, Rat, Sheep, Frog, Zebrafish
Clone: CBCNC-011
Application*: E, IH, WB, IP, F
Datasheet SDS

Rabbit Anti-CLDN5 Recombinant Antibody (CBWJC-2770) (V2LY-1206-LY51)

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Target: CLDN5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2770
Application*: P, WB
Datasheet SDS

Mouse Anti-CLDN5 Recombinant Antibody (CBYY-C3191) (V2LY-1206-LY50)

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Target: CLDN5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C3191
Application*: P, WB
Datasheet SDS

Rabbit Anti-CLDN5 Recombinant Antibody (CBYY-C3167) (V2LY-1206-LY49)

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Target: CLDN5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C3167
Application*: E, P
Datasheet SDS

Mouse Anti-CLDN5 Recombinant Antibody (CBYY-C3141) (V2LY-1206-LY48)

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Target: CLDN5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Monkey
Clone: CBYY-C3141
Application*: E, F
Datasheet SDS

Mouse Anti-CLDN5 Recombinant Antibody (CBFYC-1906) (V2LY-1206-LY47)

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Target: CLDN5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1906
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-CLDN5 Recombinant Antibody (3D8) (V2LY-1206-LY46)

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Target: CLDN5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D8
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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