This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Full Name
claudin 5
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.
Biological Process
Bicellular tight junction assembly Source: GO_Central Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB Cell adhesion Source: GO_Central Cell-cell junction assembly Source: UniProtKB Establishment of blood-retinal barrier Source: ARUK-UCL Face morphogenesis Source: UniProtKB Learning Source: UniProtKB Maintenance of blood-brain barrier Source: ARUK-UCL Negative regulation of angiogenesis Source: ARUK-UCL Negative regulation of cell migration Source: ARUK-UCL Negative regulation of gene expression Source: ARUK-UCL Negative regulation of vascular permeability Source: ARUK-UCL Outflow tract morphogenesis Source: UniProtKB Positive regulation of bicellular tight junction assembly Source: ARUK-UCL Positive regulation of cell population proliferation Source: ARUK-UCL Positive regulation of establishment of endothelial barrier Source: UniProtKB Positive regulation of gene expression Source: ARUK-UCL Positive regulation of protein binding Source: ARUK-UCL Regulation of bicellular tight junction assembly Source: Reactome Roof of mouth development Source: UniProtKB Tight junction assembly Source: ARUK-UCL Transforming growth factor beta receptor signaling pathway Source: UniProtKB
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Datasheet