DLC1

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.

Full Name

DLC1

Function

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Biological Process

Actin cytoskeleton organization Source: UniProtKB
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic process Source: UniProtKB
Focal adhesion assembly Source: UniProtKB
Forebrain development Source: UniProtKB
Heart morphogenesis Source: UniProtKB
Hindbrain morphogenesis Source: UniProtKB
Negative regulation of cell migration Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of focal adhesion assembly Source: UniProtKB
Negative regulation of Rho protein signal transduction Source: UniProtKB
Negative regulation of stress fiber assembly Source: UniProtKB
Neural tube closure Source: UniProtKB
Positive regulation of execution phase of apoptosis Source: UniProtKB
Positive regulation of protein dephosphorylation Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Regulation of Rho protein signal transduction Source: GO_Central
Regulation of small GTPase mediated signal transduction Source: Reactome
Signal transduction Source: InterPro

Cellular Location

Cytoplasm; Focal adhesion; Membrane. Colocalizes with EF1A1 at actin-rich regions in the cell periphery.