DNAJB1

This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

DnaJ Heat Shock Protein Family (Hsp40) Member B1

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).

Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Chaperone cofactor-dependent protein refolding Source: UniProtKB
Forebrain development Source: Ensembl
Negative regulation of inclusion body assembly Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Negative regulation of transcription from RNA polymerase II promoter in response to stress Source: UniProtKB
Positive regulation of ATPase activity Source: BHF-UCL
Regulation of cellular response to heat Source: Reactome
Response to unfolded protein Source: ProtInc

Nucleus; Nucleolus; Cytoplasm. Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.