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DNAJB1

This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member B1
Function
Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401).

Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Biological Process
Chaperone cofactor-dependent protein refolding Source: UniProtKB
Forebrain development Source: Ensembl
Negative regulation of inclusion body assembly Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Negative regulation of transcription from RNA polymerase II promoter in response to stress Source: UniProtKB
Positive regulation of ATPase activity Source: BHF-UCL
Regulation of cellular response to heat Source: Reactome
Response to unfolded protein Source: ProtInc
Cellular Location
Nucleus; Nucleolus; Cytoplasm. Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
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Anti-DNAJB1 antibodies

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Mouse Anti-DNAJB1 Recombinant Antibody (CBFYH-0131) (CBMAB-H0994-FY)

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Target: DNAJB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYH-0131
Application*: WB
Datasheet SDS

Mouse Anti-DNAJB1 Recombinant Antibody (CBYCD-337) (CBMAB-D1283-YC)

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Target: DNAJB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cattle
Clone: CBYCD-337
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DNAJB1 Recombinant Antibody (1A12) (CBMAB-D1273-YC)

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Target: DNAJB1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A12
Application*: E, WB
Datasheet SDS

Rabbit Anti-DNAJB1 Recombinant Antibody (H0991) (V2LY-0425-LY626)

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Target: DNAJB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: H0991
Application*: IH, WB
Datasheet SDS

Mouse Anti-DNAJB1 Recombinant Antibody (D1281) (V2LY-0425-LY624)

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Target: DNAJB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: D1281
Application*: WB, IH, IF, IP, E
Datasheet SDS

Mouse Anti-DNAJB1 Recombinant Antibody (1H8) (V2LY-0425-LY623)

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Target: DNAJB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 1H8
Application*: F, WB
Datasheet SDS

Mouse Anti-DNAJB1 Recombinant Antibody (1F9) (V2LY-0425-LY622)

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Target: DNAJB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog
Clone: 1F9
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-DNAJB1 Recombinant Antibody (A115) (CBMAB-AP10043LY)

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Target: DNAJB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Yeast
Clone: A115
Application*: E, IP, WB
Datasheet SDS

Rabbit Anti-DNAJB1 Recombinant Antibody (G.779.5) (CBMAB-H0991-FY)

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Target: DNAJB1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: G.779.5
Application*: P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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