FKBP4
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]
Full Name
FK506 Binding Protein 4
Function
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Biological Process
Chaperone-mediated protein folding Source: UniProtKB
Copper ion transport Source: Ensembl
Negative regulation of microtubule polymerization Source: Ensembl
Negative regulation of microtubule polymerization or depolymerization Source: UniProtKB
Negative regulation of neuron projection development Source: UniProtKB
Protein folding Source: ProtInc
Protein peptidyl-prolyl isomerization Source: GO_Central
Copper ion transport Source: Ensembl
Negative regulation of microtubule polymerization Source: Ensembl
Negative regulation of microtubule polymerization or depolymerization Source: UniProtKB
Negative regulation of neuron projection development Source: UniProtKB
Protein folding Source: ProtInc
Protein peptidyl-prolyl isomerization Source: GO_Central
Cellular Location
Nucleus; Cytosol; Cytoskeleton; Mitochondrion; Axon. Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).
PTM
Phosphorylation by CK2 results in loss of HSP90 binding activity.
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Anti-FKBP4 antibodies
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CompareTarget: FKBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Dog, Hamster
Clone: Hi52C
Application*: WB, IH, IF, IP
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 268
Application*: ELISA, IF, IHC, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 24
Application*: ELISA, IF, IHC, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CAP1035
Application*: Dot blot, ELISA, IHC, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 5C11
Application*: WB, E
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Dog, Hamster, Human, Mouse, Rabbit, Rat
Clone: CBXF-3346
Application*: IH, IP, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3051
Application*: E, IH, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-3050
Application*: E, IH, IP, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Guinea pig, Hamster, Human, Monkey, Rabbit
Clone: CBXF-2732
Application*: E, IC, IH, IP, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0713
Application*: P, IP, WB
Target: FKBP4
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2644
Application*: WB, IH
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0078
Application*: E, WB, IF, F, IH
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0712
Application*: IH, IP, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit
Clone: CBXF-0710
Application*: E, IC, IH, IP, R, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Guinea pig, Hamster, Human, Mouse, Rabbit
Clone: KN382/EC1
Application*: IF, P, IP, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: AT4D3
Application*: E, IH, P, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2314
Application*: E, F, IF, IH, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Dog, Hamster
Clone: CBXF-0709
Application*: WB, P, IP
Target: FKBP4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1230
Application*: WB, IP, P, F
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0714
Application*: WB, P, F, IF
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2031
Application*: E, IF, IH, WB
Target: FKBP4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0711
Application*: E, WB
Target: FKBP4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1229
Application*: WB, P, F, IF
Target: FKBP4
Specificity: Human
Target: FKBP4
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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