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gp120/gp160 (Pan)

Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41. Attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. Acts as a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. HIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells.
Full Name
Envelope glycoprotein GP120/160

Anti-gp120/gp160 (Pan) antibodies

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Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (10E9) (CBMAB-YT065LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 10E9
Application*: WB, ELISA, IP, IF
Datasheet SDS

Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (13E7) (CBMAB-YT162LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 13E7
Application*: WB, ELISA, IP, IF
Datasheet SDS

Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (1G9) (CBMAB-YT134LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 1G9
Application*: WB, ELISA, IP, IF
Datasheet SDS

Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (6B3) (CBMAB-YT129LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG2a
Specificity: HIV-1
Clone: 6B3
Application*: WB, ELISA, IP, IF
Datasheet SDS

Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (13B3) (CBMAB-YT127LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 13B3
Application*: WB, ELISA, IP, IF
Datasheet SDS

Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (15C5) (CBMAB-YT125LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 15C5
Application*: WB, ELISA, IP, IF
Datasheet SDS

Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (12C2) (CBMAB-YT119LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 12C2
Application*: WB, ELISA, IP, IF
Datasheet SDS

Mouse Anti-gp120/gp160 (Pan) Recombinant Antibody (14C3) (CBMAB-YT100LY)

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Target: gp120/gp160 (Pan)
Host: Mouse
Antibody Isotype: IgG1
Specificity: HIV-1
Clone: 14C3
Application*: WB, ELISA, IP, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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