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GRK1

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq]
Full Name
G protein-coupled receptor kinase 1
Function
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941).

This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).

May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).
Biological Process
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of rhodopsin mediated signaling pathway Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Rhodopsin mediated signaling pathway Source: ProtInc
Visual perception Source: ProtInc
Cellular Location
Membrane; Photoreceptor outer segment. Subcellular location is not affected by light or dark conditions.
Involvement in disease
Night blindness, congenital stationary, Oguchi type 2 (CSNBO2):
A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation.
PTM
Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.
Farnesylation is required for full activity.

Anti-GRK1 antibodies

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Mouse Anti-GRK1 Recombinant Antibody (466630) (CBMAB-G0796-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 466630
Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (8H207) (CBMAB-R0538-CN)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 8H207
Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (CBFYH-0483) (CBMAB-H0101-FY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: CBFYH-0483
Application*: WB, IH, IF, C

Mouse Anti-GRK1 Recombinant Antibody (CBFYH-0484) (CBMAB-H1354-FY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle, Chicken
Clone: CBFYH-0484
Application*: WB, IF

Mouse Anti-GRK1 Recombinant Antibody (1G8) (CBMAB-G4977-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1G8
Application*: E, WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1775) (CBMAB-G4980-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1775
Application*: SE, E, WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1776) (CBMAB-G4981-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1776
Application*: E, WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1777) (CBMAB-G4982-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1777
Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1778) (CBMAB-G4983-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-1778
Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1779) (CBMAB-G4984-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1779
Application*: IF, IP, WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1780) (CBMAB-G4985-LY)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1780
Application*: E, EC, WB

Mouse Anti-GRK1 Monoclonal Antibody (D11) (CBMAB-1338-YC)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Cattle
Clone: D11
Application*: IC, IF, C, IP, WB

Mouse Anti-GRK1 Monoclonal Antibody (G8) (CBMAB-1339-YC)

Datasheet SDS
Target: GRK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Chicken, Cattle, Dog
Clone: G8
Application*: IC, IF, C, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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