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GRK1

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq]

Full Name

G protein-coupled receptor kinase 1

Function

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941).

This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity).

May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).

Biological Process

Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of rhodopsin mediated signaling pathway Source: UniProtKB
Regulation of signal transduction Source: GO_Central
Rhodopsin mediated signaling pathway Source: ProtInc
Visual perception Source: ProtInc

Cellular Location

Membrane; Photoreceptor outer segment. Subcellular location is not affected by light or dark conditions.

Involvement in disease

Night blindness, congenital stationary, Oguchi type 2 (CSNBO2):
A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation.

PTM

Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.
Farnesylation is required for full activity.

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Anti-GRK1 antibodies

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Mouse Anti-GRK1 Monoclonal Antibody (G8) (CBMAB-1339-YC)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Chicken, Cattle, Dog

Clone: G8

Application*: IC, IF, C, WB

Mouse Anti-GRK1 Monoclonal Antibody (D11) (CBMAB-1338-YC)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Cattle

Clone: D11

Application*: IC, IF, C, IP, WB

Mouse Anti-GRK1 Recombinant Antibody (8H207) (CBMAB-R0538-CN)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 8H207

Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1780) (CBMAB-G4985-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBLG1-1780

Application*: E, EC, WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1779) (CBMAB-G4984-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1779

Application*: IF, IP, WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1778) (CBMAB-G4983-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBLG1-1778

Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1777) (CBMAB-G4982-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1777

Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1776) (CBMAB-G4981-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBLG1-1776

Application*: E, WB

Mouse Anti-GRK1 Recombinant Antibody (CBLG1-1775) (CBMAB-G4980-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBLG1-1775

Application*: SE, E, WB

Mouse Anti-GRK1 Recombinant Antibody (1G8) (CBMAB-G4977-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1G8

Application*: E, WB

Mouse Anti-GRK1 Recombinant Antibody (466630) (CBMAB-G0796-LY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 466630

Application*: WB

Mouse Anti-GRK1 Recombinant Antibody (CBFYH-0484) (CBMAB-H1354-FY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Cattle, Chicken

Clone: CBFYH-0484

Application*: WB, IF

Mouse Anti-GRK1 Recombinant Antibody (CBFYH-0483) (CBMAB-H0101-FY)

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Target: GRK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Cattle

Clone: CBFYH-0483

Application*: WB, IH, IF, C

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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