LYAR

Diseases associated with LYAR include Neuroblastoma.

Full Name

Ly1 antibody reactive

Function

Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227).
Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918).
In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580).
Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918).
Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131).
In addition, inhibits NF-kappa-B-mediated expression of pro-inflammatory cytokines (PubMed:31413131).
Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity).
Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).

Biological Process

Erythrocyte developmentManual Assertion Based On ExperimentIMP:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Negative regulation of innate immune responseManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of phagocytosisISS:UniProtKB
Positive regulation of transcription by RNA polymerase IManual Assertion Based On ExperimentIDA:ARUK-UCL
rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Nucleus, nucleolus
Cytoplasm
Cell projection, cilium, photoreceptor outer segment
Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (PubMed:24495227).
Associated with cytoplasmic ribosomes, but not polysomes, as a component of the 60S subunit (PubMed:24990247).
In the retina, predominantly expressed in photoreceptor outer segments (By similarity).
In the nucleolus, colocalizes with nucleolin/NCL, therefore may reside in the dense fibrillar component (DFC) (By similarity).