MGMT

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]

O-6-Methylguanine-DNA Methyltransferase

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Cellular response to ionizing radiation Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Cellular response to oxidative stress Source: Ensembl
DNA dealkylation involved in DNA repair Source: Ensembl
DNA ligation Source: ProtInc
DNA repair Source: GO_Central
Mammary gland epithelial cell differentiation Source: Ensembl
Negative regulation of apoptotic process Source: BHF-UCL
Positive regulation of double-strand break repair Source: BHF-UCL
Regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Response to ethanol Source: Ensembl
Response to folic acid Source: Ensembl
Response to toxic substance Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl

Nucleus