MGMT

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Full Name
O-6-Methylguanine-DNA Methyltransferase
Function
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Biological Process
Cellular response to ionizing radiation Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Cellular response to oxidative stress Source: Ensembl
DNA dealkylation involved in DNA repair Source: Ensembl
DNA ligation Source: ProtInc
DNA repair Source: GO_Central
Mammary gland epithelial cell differentiation Source: Ensembl
Negative regulation of apoptotic process Source: BHF-UCL
Positive regulation of double-strand break repair Source: BHF-UCL
Regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Response to ethanol Source: Ensembl
Response to folic acid Source: Ensembl
Response to toxic substance Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl
Cellular Location
Nucleus
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Anti-MGMT antibodies

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Rabbit Anti-MGMT Recombinant Antibody (
10G7) (V2LY-0725-LY1545)

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Target: MGMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10G7
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBT2745) (V2LY-0625-LY269)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2745
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBT4344) (V2LY-0625-LY227)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4344
Application*: WB
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (A1081) (CBMAB-AP11850LY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1081
Application*: IF, IHC, IP, WB
Datasheet SDS

Rabbit Anti-MGMT Recombinant Antibody (E9O4V) (CBMAB-CP1533-LY)

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Target: MGMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: E9O4V
Application*: WB, IP, P
Datasheet SDS

Rabbit Anti-MGMT Recombinant Antibody (E6M7V) (CBMAB-CP1532-LY)

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Target: MGMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: E6M7V
Application*: WB, IP, IF (IC)
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-2185) (CBMAB-M2367-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYM-2185
Application*: IH, IF
Datasheet SDS

Mouse Anti-MGMT (AA 1-100) Recombinant Antibody (CBFYM-2184) (CBMAB-M2366-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYM-2184
Application*: E, IF, IH, IP
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-2183) (CBMAB-M2365-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2183
Application*: F, IF, P, IP, WB
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-2182) (CBMAB-M2364-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-2182
Application*: E, F, WB
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-0637) (CBMAB-M0772-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYM-0637
Application*: E, IH, IP
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-0636) (CBMAB-M0771-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0636
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-0635) (CBMAB-M0770-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0635
Application*: F, IH, WB
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-0634) (CBMAB-M0769-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0634
Application*: IF, IH, IP, WB
Datasheet SDS

Mouse Anti-MGMT (AA 1-100) Recombinant Antibody (CBFYM-0517) (CBMAB-M0645-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYM-0517
Application*: E, IH
Datasheet SDS

Mouse Anti-MGMT Recombinant Antibody (CBFYM-0373) (CBMAB-M0462-FY)

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Target: MGMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0373
Application*: WB, F, IH, IF, P, F, MC
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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