MKI67
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.
Full Name
marker of proliferation Ki-67
Alternative Names
Marker Of Proliferation Ki-67; Antigen Identified By Monoclonal Antibody Ki-67; Protein Phosphatase 1, Regulatory Subunit 105; Antigen KI-67; Antigen Ki67; Proliferation-Related Ki-67 Antigen;
Function
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226).
Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226).
Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226).
Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551).
Does not contribute to the internal structure of mitotic chromosomes (By similarity).
May play a role in chromatin organization (PubMed:24867636).
It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226).
Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226).
Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551).
Does not contribute to the internal structure of mitotic chromosomes (By similarity).
May play a role in chromatin organization (PubMed:24867636).
It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Biological Process
Cell cycle Source: UniProtKB-KW
Cell population proliferation Source: ProtInc
Regulation of chromatin organization Source: UniProtKB
Regulation of chromosome segregation Source: UniProtKB
Regulation of mitotic nuclear division Source: UniProtKB
Cell population proliferation Source: ProtInc
Regulation of chromatin organization Source: UniProtKB
Regulation of chromosome segregation Source: UniProtKB
Regulation of mitotic nuclear division Source: UniProtKB
Cellular Location
Nucleus
nucleolus
Other locations
Chromosome
Note: Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106).
nucleolus
Other locations
Chromosome
Note: Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface (PubMed:27362226). Associates with satellite DNA in G1 phase (PubMed:9510506). Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes (PubMed:15896774, PubMed:22002106). Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix (PubMed:22002106).
PTM
Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604). Hyperphosphorylated form does not bind DNA.
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Anti-MKI67 antibodies
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CompareTarget: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: SP6
Application*: IC, IF, C, P, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC180
Application*: P, IF
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1114
Application*: ICC, IF, IHC, WB
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A1113
Application*: FC, ICC, IF, IHC, IP, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1112
Application*: ELISA, IHC
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A1111
Application*: FC, ICC, IF, IHC, IP, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1110
Application*: ICC, IHC, IP, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1109
Application*: IHC
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A1108
Application*: IHC
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1107
Application*: IHC
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1106
Application*: IF, IHC
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB376A
Application*: ELISA, IHC
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C12B2
Application*: ELISA, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Application*: WB
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM360
Application*: IHC, WB
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR021E
Application*: WB, IHC, ICC, IHC-IF, ICC-IF, F, mIF
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb143
Application*: WB, IH, IF
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYM-2257
Application*: IH, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2256
Application*: F, IC, P, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2255
Application*: WB, IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2254
Application*: E, IF, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2253
Application*: WB, IC, P, C, E, IP, IF, F
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-2252
Application*: E, IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2251
Application*: P
Target: MKI67
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2250
Application*: P
Target: MKI67
Host: Rabbit
Specificity: Human
Clone: CBFYM-0650
Application*: F, IF, IH, IP, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C12B2
Application*: WB, IH, E
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 8K5
Application*: IH
Target: MKI67
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse, Human
Clone: 11F6
Application*: IF, EM, IF, F
Target: MKI67
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: PP-67
Application*: C, P, WB
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D2H10
Application*: P
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C16-I
Application*: IH, P
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: BS4
Application*: P
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9H7
Application*: WB, IH
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 9H428
Application*: IH
Target: MKI67
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C3
Application*: WB, IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8B11
Application*: IH, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7D9
Application*: WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 7B8
Application*: E, IF, WB
Target: MKI67
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D7
Application*: P, F
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Human, Rat
Clone: 4A8
Application*: IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A1
Application*: IA, IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D11
Application*: IH, P, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B8
Application*: IH, WB
Target: MKI67
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3A11
Application*: IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q476
Application*: F, IC, IH, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B4
Application*: WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F11
Application*: IH, WB
Target: MKI67
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D9
Application*: IH
Target: MKI67
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human
Clone: 16A8
Application*: F, IF, EM
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 15A4
Application*: IH, WB
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 14B30
Application*: E, IH, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13F12
Application*: IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B444
Application*: E, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13B443
Application*: E, IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13B11
Application*: IH
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 12H15L5
Application*: CI, F, IC, IF
Target: MKI67
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B6
Application*: IH, 1:150
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: 8D5
Application*: WB, E, IC/IF, P
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1297A
Application*: F, IC/IF, F
Target: MKI67
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Dog, Monkey, Mouse, Rat
Clone: SolA15
Application*: F
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D3B5
Application*: IF, F
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Monkey
Clone: B56
Application*: F, WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Dog
Clone: 20Raj1
Application*: IC, IF, P
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBLY1-011
Application*: P, IC/IF
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-010
Application*: WB, P, C, F, IC/IF
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: KI67
Application*: F, IC, IF
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3E6
Application*: E, M
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT803
Application*: P, IF, IC
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT804
Application*: WB, P, IF, E
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT805
Application*: WB, E
Target: MKI67
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT806
Application*: P, IF, E
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3414
Application*: WB, IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4794
Application*: IH
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4777
Application*: WB
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3073
Application*: WB, IH, F
Target: MKI67
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2857
Application*: IH, F
Target: MKI67
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR-0032
Application*: ELISA
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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