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NANOG

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Full Name

Nanog Homeobox

Function

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768).

Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

Biological Process

Cell differentiation Source: HGNC-UCL
Endodermal cell fate specification Source: MGI
Positive regulation of stem cell proliferation Source: HGNC-UCL
Positive regulation of transcription by RNA polymerase II Source: MGI
Regulation of cell differentiation Source: HGNC-UCL
Regulation of gene expression Source: UniProtKB
Regulation of transcription, DNA-templated Source: HGNC-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell population maintenance Source: UniProtKB
Stem cell population maintenance Source: BHF-UCL

Cellular Location

Nucleus

Anti-NANOG antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-NANOG Recombinant Antibody (CB19A) (CBMAB-CA019LY)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CB19A

Application*: ELISA, WB, ICC, IF, FC

Mouse Anti-NANOG Recombinant Antibody (IHC634) (CBMAB-MA182-YC)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: IHC634

Application*: IH

Mouse Anti-NANOG Recombinant Antibody (8A1D11) (CBMAB-R4324-CN)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 8A1D11

Application*: E, WB, IF, F

Rat Anti-NANOG Recombinant Antibody (SER211) (CBMAB-N1122-WJ)

SDS

Target: NANOG

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: SER211

Application*: WB

Mouse Anti-NANOG Recombinant Antibody (PR-3F6) (CBMAB-N1121-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: PR-3F6

Application*: WB, E

Mouse Anti-NANOG Recombinant Antibody (PR-2E11) (CBMAB-N1120-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: PR-2E11

Application*: E, WB

Mouse Anti-NANOG Recombinant Antibody (P5A10AT) (CBMAB-N1119-WJ)

SDS

Target: NANOG

Host: Mouse

Specificity: Human

Clone: P5A10AT

Application*: E, WB, IH

Mouse Anti-NANOG Recombinant Antibody (NNG-811) (CBMAB-N1118-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: NNG-811

Application*: WB, IP, E, P, IC

Mouse Anti-NANOG Recombinant Antibody (CBWJN-0622) (CBMAB-N1117-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0622

Application*: WB, BI

Mouse Anti-NANOG Recombinant Antibody (CBWJN-0611) (CBMAB-N1116-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0611

Application*: IC, IF, P, WB

Mouse Anti-NANOG Recombinant Antibody (F-8) (CBMAB-N1114-WJ)

SDS

Target: NANOG

Host: Mouse

Specificity: Mouse

Clone: F-8

Application*: WB, IP, IF, E

Rabbit Anti-NANOG Recombinant Antibody (D2A3) (CBMAB-N1113-WJ)

SDS

Target: NANOG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: D2A3

Application*: WB, IP, IF, F, CI

Rabbit Anti-NANOG Recombinant Antibody (D1G10) (CBMAB-N1112-WJ)

SDS

Target: NANOG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: D1G10

Application*: IP, CI

Mouse Anti-NANOG Recombinant Antibody (3A12) (CBMAB-N1111-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3A12

Application*: E, IF

Mouse Anti-NANOG Recombinant Antibody (2C4) (CBMAB-N1110-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 2C4

Application*: E, F, IF, IH, WB

Mouse Anti-NANOG Recombinant Antibody (2C11) (CBMAB-N1109-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2C11

Application*: E, WB

Mouse Anti-NANOG Recombinant Antibody (1F8) (CBMAB-N1108-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1F8

Application*: E, WB

Mouse Anti-NANOG Recombinant Antibody (CBWJN-0034) (CBMAB-N1107-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0034

Application*: E, WB

Mouse Anti-NANOG Recombinant Antibody (10E42) (CBMAB-N1106-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10E42

Application*: IF, WB

Mouse Anti-NANOG Recombinant Antibody (10C313) (CBMAB-N1105-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 10C313

Application*: E, IH, WB

Mouse Anti-NANOG Recombinant Antibody (2E11) (CBMAB-N1103-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2E11

Application*: E, IF, WB

Mouse Anti-NANOG Recombinant Antibody (CBWJN-1165) (CBMAB-N1102-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBWJN-1165

Application*: WB, F

Recombinant Anti-NANOG Recombinant Antibody (CBWJN-0787) (CBMAB-N0125-WJ)

SDS

Target: NANOG

Host: Recombinant

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0787

Application*: F

Mouse Anti-NANOG Recombinant Antibody (N31-355) (CBMAB-N0123-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: N31-355

Application*: WB, BI

Mouse Anti-NANOG Recombinant Antibody (CBWJN-0636) (CBMAB-N0122-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBWJN-0636

Application*: BI, WB

Rabbit Anti-NANOG Recombinant Antibody (CBWJN-0944) (CBMAB-N0121-WJ)

SDS

Target: NANOG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-0944

Application*: WB, P, IC

Rat Anti-NANOG Recombinant Antibody (CBWJN-0592) (CBMAB-N0120-WJ)

SDS

Target: NANOG

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBWJN-0592

Application*: IC, IF, WB

Rabbit Anti-NANOG Recombinant Antibody (D73G4) (CBMAB-N0119-WJ)

SDS

Target: NANOG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D73G4

Application*: WB, P, IF, F

Mouse Anti-NANOG Recombinant Antibody (60CT77.1.1) (CBMAB-N0118-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 60CT77.1.1

Application*: E, IH, WB

Mouse Anti-NANOG Recombinant Antibody (60CT70.5.12) (CBMAB-N0117-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 60CT70.5.12

Application*: IH, WB

Mouse Anti-NANOG Recombinant Antibody (5A10) (CBMAB-N0116-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse

Clone: 5A10

Application*: WB, F, E, IH, P

Mouse Anti-NANOG Recombinant Antibody (CBWJN-0299) (CBMAB-N0115-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0299

Application*: F, IC, IF, WB

Mouse Anti-NANOG Recombinant Antibody (1E6C4) (CBMAB-N0114-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1E6C4

Application*: WB, E, IF

Mouse Anti-NANOG Recombinant Antibody (16H3A48) (CBMAB-N0113-WJ)

SDS

Target: NANOG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 16H3A48

Application*: WB, IS, IF

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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