P2RX4

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

Full Name

Purinergic Receptor P2X 4

Function

Receptor for extracellularly released ATP acting as a ligand-gated ion channel that plays multiple role in immunity and central nervous system physiology (PubMed:35165166).
Plays a key role in initial steps of T-cell activation and Ca2+ microdomain formation (By similarity).
Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity).
Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166).
Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity).

Biological Process

Apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Behavioral response to painISS:ARUK-UCL
Calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Calcium-mediated signalingManual Assertion Based On ExperimentTAS:ARUK-UCL
Cellular response to ATPManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to zinc ionISS:UniProtKB
Endothelial cell activationManual Assertion Based On ExperimentTAS:BHF-UCL
Ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Membrane depolarizationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of cardiac muscle hypertrophyManual Assertion Based On ExperimentIMP:BHF-UCL
Neuronal action potentialIEA:Ensembl
Positive regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of calcium ion transport1 PublicationNAS:BHF-UCL
Positive regulation of calcium ion transport into cytosolManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of calcium-mediated signalingManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of endothelial cell chemotaxisManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of microglial cell migrationISS:ARUK-UCL
Positive regulation of nitric oxide biosynthetic process1 PublicationNAS:BHF-UCL
Positive regulation of prostaglandin secretion1 PublicationNAS:BHF-UCL
Positive regulation of protein kinase B signalingISS:ARUK-UCL
Purinergic nucleotide receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of blood pressureManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cardiac muscle contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of chemotaxisISS:ARUK-UCL
Regulation of sodium ion transportBy SimilarityISS:BHF-UCL
Relaxation of cardiac muscleManual Assertion Based On ExperimentIMP:BHF-UCL
Response to ATPManual Assertion Based On ExperimentIDA:BHF-UCL
Response to axon injuryISS:ARUK-UCL
Response to fluid shear stressManual Assertion Based On ExperimentIDA:BHF-UCL
Response to ischemiaISS:ARUK-UCL
Sensory perception of painBy SimilarityISS:ARUK-UCL
Sensory perception of touchISS:ARUK-UCL
Signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
Tissue homeostasis1 PublicationNAS:BHF-UCL

Topology

Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-338
Helical: 339-359
Cytoplasmic: 360-388