RIDA

RIDA (Reactive Intermediate Imine Deaminase A Homolog) is a Protein Coding gene.

Full Name

reactive intermediate imine deaminase A homolog

Function

Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.
Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:8973653, PubMed:30930054).
Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054).
RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054).

Biological Process

Biological Process brain developmentIEA:Ensembl
Biological Process G1 to G0 transitionIEA:Ensembl
Biological Process kidney developmentIEA:Ensembl
Biological Process L-threonine catabolic process to glycineTAS:Reactome
Biological Process lipid metabolic processIEA:UniProtKB-KW
Biological Process lung developmentIEA:Ensembl
Biological Process mRNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA destabilizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of epithelial cell proliferationIEA:Ensembl
Biological Process negative regulation of translationISS:UniProtKB
Biological Process organonitrogen compound catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to lipidIEA:Ensembl
Biological Process response to saltIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Peroxisome
Mitochondrion
Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.