SLC27A1

solute carrier family 27 (fatty acid transporter), member 1

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534, PubMed:20530735, PubMed:21395585, PubMed:28178239).
Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity).
Probably involved in fatty acid transport across the blood barrier (PubMed:21395585).

Biological Process adiponectin-activated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process biotin import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process biotin transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process cardiolipin biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process export across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process glucose import in response to insulin stimulusISS:ARUK-UCL
Biological Process lipid transport across blood-brain barrierManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process long-chain fatty acid import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process long-chain fatty acid import into cellManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process long-chain fatty acid transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process medium-chain fatty acid transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of phospholipid biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phosphatidic acid biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phosphatidylcholine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phosphatidylethanolamine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phosphatidylglycerol biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phosphatidylinositol biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process phosphatidylserine biosynthetic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of heat generationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of triglyceride biosynthetic processISS:UniProtKB
Biological Process response to coldManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to insulinManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL

Cell membrane
Endomembrane system
Cytoplasm
Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes.

Extracellular: 1-13
Helical: 14-34
Cytoplasmic: 35-646