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SST

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells.
Full Name
Somatostatin
Function
Somatostatin-14
Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin.
Neuronostatin
May enhance low-glucose-induced glucagon release by pancreatic alpha cells (By similarity).
This effect may be mediated by binding to GPR107 and PKA activation (By similarity).
May regulate cardiac contractile function (By similarity).
May compromise cardiomyocyte viability (By similarity).
In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity).
May also have anxiolytic and anorexigenic effects (By similarity).
May play a role in arterial pressure regulation (By similarity).
May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (PubMed:29615476).
Biological Process
Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process digestionManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process hormone-mediated apoptotic signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process hyperosmotic responseIEA:Ensembl
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to acidic pHIEA:Ensembl
Biological Process response to amino acidIEA:Ensembl
Biological Process response to heatIEA:Ensembl
Biological Process response to nutrientManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process response to steroid hormoneIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Cellular Location
Secreted
PTM
C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure.

Anti-SST antibodies

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Target: SST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 9H33L7
Application*: IF, IC, F, WB
Target: SST
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: ICDCLS
Application*: P
Target: SST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7G5
Application*: E, F, IH, P, WB
Target: SST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR3360(2)
Application*: E, P
Target: SST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR3359(2)
Application*: C, P
Target: SST
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2442
Application*: WB
Target: SST
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-2443
Application*: WB
Target: SST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1489
Application*: P
Target: SST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1490
Application*: E, P
Target: SST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: SOM-018
Application*: IF, IH, C, P
Target: SST
Host: Rat
Antibody Isotype: IgG2b
Specificity: Guinea pig, Human, Mouse, Pig, Rat
Clone: YC7
Application*: C, P
Target: SST
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-5980
Application*: F, IC, IF, WB
Target: SST
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0736
Application*: C, P
Target: SST
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0738
Application*: IH
Target: SST
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXS-1974
Application*: IH, IC
Target: SST
Host: Mouse
Specificity: Human
Clone: CBXS-2234
Application*: WB, IP, IF, P, E
Target: SST
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBXS-2334
Application*: IH
Target: SST
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2459
Application*: E, F, IH, WB
Target: SST
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-2976
Application*: IH
Target: SST
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3424
Application*: E, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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