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VCAN

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
VCAN
Function
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
Biological Process
Biological Process cell adhesion Source:ProtInc1 Publication
Biological Process cell recognition Source:ProtInc1 Publication
Biological Process central nervous system development Source:GO_Central1 Publication
Biological Process glial cell migration Source:BHF-UCL
Biological Process osteoblast differentiation Source:UniProtKB1 Publication
Biological Process skeletal system development Source:GO_Central1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Cell projection, cilium, photoreceptor outer segment
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix
Involvement in disease
Wagner vitreoretinopathy (WGVRP):
A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia.
PTM
Phosphorylated by FAM20C in the extracellular medium.
Proteolytically cleaved by ADAMTS5 and ADAMTS15 in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.

Anti-VCAN antibodies

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Target: VCAN
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-1366
Application*: WB
Target: VCAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Pig, Rat
Clone: 12C5
Application*: E, P, B, IF, IH, IP, WB
Target: VCAN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat, Human
Clone: 6A38
Application*: E, IF, IH, IP, WB
Target: VCAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 5H26
Application*: C, WB
Target: VCAN
Host: Mouse
Antibody Isotype: IgM
Specificity: Chicken, Cattle, Human, Mouse
Clone: 10B2233
Application*: IF, IH
Target: VCAN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EPR12277
Application*: WB, P
Target: VCAN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: S351-23
Application*: WB, IC/IF
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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