WNT9A

WNT9A is a protein-coding gene. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. This gene is a member of the WNT gene family and expressed in gastric cancer cell lines. Among its related pathways are PI3K-Akt signaling pathway and Gastric cancer. An important paralog of this gene is WNT9B.

Full Name

Wnt family member 9A

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.

Biological Process

Biological Process canonical Wnt signaling pathway Source:WormBase1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cornea development in camera-type eye Source:BHF-UCLBy Similarity
Biological Process embryonic skeletal joint development Source:BHF-UCL
Biological Process iris morphogenesis Source:BHF-UCLBy Similarity
Biological Process negative regulation of cell population proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of chondrocyte differentiation Source:BHF-UCL
Biological Process neuron differentiation Source:UniProtKB

Cellular Location

Secreted, extracellular space, extracellular matrix
Secreted

PTM

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.