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CXCR3

CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CXCR5.
Full Name
C-X-C Motif Chemokine Receptor 3
Function
Isoform 1:
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716).

Binds to CCL21. Probably promotes cell chemotaxis response.

Isoform 2:
Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716).

Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.

Isoform 3:
Mediates the activity of CXCL11.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: BHF-UCL
Chemokine (C-C motif) ligand 11 production Source: UniProtKB
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: GO_Central
Inflammatory response Source: InterPro
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of endothelial cell proliferation Source: UniProtKB
Negative regulation of execution phase of apoptosis Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of chemotaxis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of execution phase of apoptosis Source: UniProtKB
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of cell adhesion Source: UniProtKB
Regulation of leukocyte migration Source: InterPro
T cell chemotaxis Source: Ensembl
Cellular Location
Isoform 1&2: Cell membrane
Topology
Extracellular: 1-53
Helical: 54-80
Cytoplasmic: 81-89
Helical: 90-110
Extracellular: 111-125
Helical: 126-147
Cytoplasmic: 148-169
Helical: 170-189
Extracellular: 190-212
Helical: 213-233
Cytoplasmic: 234-255
Helical: 256-277
Extracellular: 278-298
Helical: 299-321
Cytoplasmic: 322-368
PTM
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.
N-glycosylated.

Anti-CXCR3 antibodies

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Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-3495
Application*: F
Target: CXCR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2098
Application*: WB, IP, IC
Target: CXCR3
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CXCR3-173
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2097
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2641
Application*: F, IH, C, N, MC
Target: CXCR3
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBXC-1937
Application*: E, WB
Target: CXCR3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1498
Application*: F
Target: CXCR3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0758
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1220
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2543
Application*: P
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2542
Application*: WB, IP, E, P, F
Target: CXCR3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-2541
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBFYC-2540
Application*: E, WB
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYC-2539
Application*: siRNA, E, F, IF, IH, WB
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2538
Application*: F, IH, N
Target: CXCR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 220803
Application*: F, MC
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 1B2D6
Application*: E, F, IF, C, WB
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Monkey
Clone: CBFYC-0383
Application*: F
Target: CXCR3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0447
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2537
Application*: F, FN, IH, N
Target: CXCR3
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CXCR3-173
Application*: N, F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C6/CXCR3
Application*: F, IH
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2AR1
Application*: C, FN, IH, N
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 49801
Application*: F, IH, N, MC
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 49801.111
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 06
Application*: P
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L328
Application*: F, IH, N
Target: CXCR3
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 1C5
Application*: E, WB
Target: CXCR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 6H1L8
Application*: F, IC, IF, WB
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBYY-C0682
Application*: F
Target: CXCR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2366
Application*: F, IC, IF, WB
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2367
Application*: F, IH, N
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-538
Application*: E, WB
Target: CXCR3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0213-14C23
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 868013
Application*: F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0223-7K22
Application*: C, N, F
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF125
Application*: ELISA, WB
Target: CXCR3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 170
Application*: ELISA, IF, IHC, WB
Target: CXCR3
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: A113
Application*: FC
Target: CXCR3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG872
Application*: WB: 1:500~1:1000 ELISA: 1:5000
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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