CXCR3

CXCR3 (C-X-C Motif Chemokine Receptor 3) is a Protein Coding gene. Diseases associated with CXCR3 include Cutaneous Lupus Erythematosus and Pulmonary Sarcoidosis. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is CXCR5.

C-X-C Motif Chemokine Receptor 3

C-X-C Motif Chemokine Receptor 3; G Protein-Coupled Receptor 9; Interferon-Inducible Protein 10 Receptor; Chemokine (C-X-C Motif) Receptor 3; IP-10 Receptor; CKR-L2; GPR9; C-X-C Chemokine Receptor Type 3; Chemokine Receptor 3; CD183 Antigen;

Isoform 1:
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716).

Binds to CCL21. Probably promotes cell chemotaxis response.

Isoform 2:
Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716).

Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.

Isoform 3:
Mediates the activity of CXCL11.

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Cell surface receptor signaling pathway Source: BHF-UCL
Chemokine (C-C motif) ligand 11 production Source: UniProtKB
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: GO_Central
Inflammatory response Source: InterPro
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of endothelial cell proliferation Source: UniProtKB
Negative regulation of execution phase of apoptosis Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of chemotaxis Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of execution phase of apoptosis Source: UniProtKB
Positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of cell adhesion Source: UniProtKB
Regulation of leukocyte migration Source: InterPro
T cell chemotaxis Source: Ensembl

Isoform 1&2: Cell membrane

Extracellular: 1-53
Helical: 54-80
Cytoplasmic: 81-89
Helical: 90-110
Extracellular: 111-125
Helical: 126-147
Cytoplasmic: 148-169
Helical: 170-189
Extracellular: 190-212
Helical: 213-233
Cytoplasmic: 234-255
Helical: 256-277
Extracellular: 278-298
Helical: 299-321
Cytoplasmic: 322-368

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.
N-glycosylated.