SUMO2
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Full Name
SUMO2
Function
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494).
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629).
Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629).
Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Biological Process
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Nucleus, PML body
Nucleus, PML body
PTM
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.
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Anti-SUMO2 antibodies
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CompareTarget: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0861
Application*: SE, E, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H8
Application*: WB, E
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S2MT-1
Application*: IF, P
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S23MT-1
Application*: IF, P, WB
Target: SUMO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-6167
Application*: IC, IF, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-2969
Application*: E, IH, WB
Target: SUMO2
Host: Mouse
Specificity: Human
Clone: CBXS-2652
Application*: E, IF, IH, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-2498
Application*: E, IF, WB
Target: SUMO2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1956
Application*: WB
Target: SUMO2
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1818
Application*: IP
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-6102
Application*: E, F, IF, P, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4460
Application*: WB, E
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4077
Application*: IC, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5951
Application*: WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Hamster, Human, Mouse, Rat
Clone: CBXS-5916
Application*: WB, IF
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-3624
Application*: WB, E, IH, IF, P
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SUMO2/1199
Application*: F, P, IF, MC
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SPM621
Application*: P, IF, F
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM572
Application*: E, F, IF, IH, IP, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SM23/496
Application*: F, IF, IH, IP, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Common fruit fly, Mouse, Frog, Zebrafish
Clone: 8A2
Application*: IF, IP, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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