ANXA2

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Annexin A2
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).
Biological Process
Angiogenesis Source: UniProtKB
Catabolism by host of symbiont protein Source: AgBase
Interleukin-12-mediated signaling pathway Source: Reactome
Membrane raft assembly Source: UniProtKB
Negative regulation by host of symbiont molecular function Source: AgBase
Negative regulation of development of symbiont involved in interaction with host Source: AgBase
Negative regulation of low-density lipoprotein particle receptor catabolic process Source: BHF-UCL
Neutrophil degranulation Source: Reactome
Osteoclast development Source: UniProtKB
Positive regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Positive regulation of low-density lipoprotein particle receptor binding Source: BHF-UCL
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of receptor-mediated endocytosis involved in cholesterol transport Source: BHF-UCL
Positive regulation of receptor recycling Source: BHF-UCL
Positive regulation of vacuole organization Source: AgBase
Positive regulation of vesicle fusion Source: UniProtKB
Vesicle budding from membrane Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Basement membrane; Melanosome. In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
PTM
Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
ISGylated.
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Anti-ANXA2 antibodies

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Mouse Anti-ANXA2 Recombinant Antibody (A2903) (CBMAB-A2903-YC)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Dog, Sheep
Clone: A2903
Application*: E, IH, WB, IF
Datasheet SDS

Mouse Anti-ANXA2 Recombinant Antibody (CB272A) (CBMAB-CA272LY)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CB272A
Application*: E, WB, P, IF, IP
Datasheet SDS

Mouse Anti-ANXA2 Recombinant Antibody (1A1E1) (CBMAB-R4272-CN)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A1E1
Application*: WB, IH
Datasheet SDS

Recombinant Mouse Anti-ANXA2 Recombinant Antibody (3D5/4) (CBMAB-XB0045-YC)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3D5/4
Application*: E, IH, IF, IP, WB
Datasheet SDS

Rabbit Anti-ANXA2 Recombinant Antibody (CBYC-A627) (CBMAB-A2905-YC)

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Target: ANXA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Pig
Clone: CBYC-A627
Application*: IF, IH, WB, FC
Datasheet SDS

Mouse Anti-ANXA2 Recombinant Antibody (CBYC-A626) (CBMAB-A2904-YC)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A626
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-ANXA2 Recombinant Antibody (ANEX 3D5/4) (CBMAB-A2901-YC)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: ANEX 3D5/4
Application*: WB, E, IH, IC, IP
Datasheet SDS

Mouse Anti-ANXA2 Recombinant Antibody (4G8) (CBMAB-A2899-YC)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G8
Application*: E, WB
Datasheet SDS

Mouse Anti-ANXA2 Recombinant Antibody (3E8-B6) (CBMAB-A2896-YC)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E8-B6
Application*: E, IF, RNAi, WB
Datasheet SDS

Mouse Anti-ANXA2 Recombinant Antibody (1G7) (CBMAB-A2895-YC)

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Target: ANXA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G7
Application*: E, IF, WB
Datasheet SDS

Rabbit Anti-ANXA2 Recombinant Antibody (
10H9) (V2LY-0725-LY1577)

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Target: ANXA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10H9
Application*: E, WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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