ENO1

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
Full Name
Enolase 1
Research Area
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209).

In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581).

May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133).

Stimulates immunoglobulin production (PubMed:1369209).

MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Biological Process
Canonical glycolysis Source: UniProtKB
Glycolytic process Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: CAFA
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: CAFA
Positive regulation of ATP biosynthetic process Source: CAFA
Positive regulation of muscle contraction Source: CAFA
Positive regulation of plasminogen activation Source: CAFA
Regulation of vacuole fusion, non-autophagic Source: GO_Central
Response to virus Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm; M line. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
Isoform MBP-1: Nucleus
PTM
ISGylated.
Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity.
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Anti-ENO1 antibodies

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Mouse Anti-ENO1 Recombinant Antibody (CBYC-A950) (CBMAB-A4388-YC)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A950
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (8G8) (CBMAB-E1329-FY)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 8G8
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (5F4) (CBMAB-BR169LY)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5F4
Application*: WB, E
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (1G1) (CBMAB-A2610-LY)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1G1
Application*: WB, E
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (N1) (CBMAB-A4387-YC)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: N1
Application*: WB, E, IP, IH
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (9F7) (CBMAB-N0739-WJ)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 9F7
Application*: WB, E
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (3B10) (CBMAB-N0737-WJ)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B10
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0874) (CBMAB-E1334-FY)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0874
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0872) (CBMAB-E1332-FY)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0872
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0868) (CBMAB-E1326-FY)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0868
Application*: WB, IP, E
Datasheet SDS

Rabbit Anti-ENO1 Recombinant Antibody (CBFYE-0138) (CBMAB-E0301-FY)

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Target: ENO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Zebrafish
Clone: CBFYE-0138
Application*: WB, F, IF, P
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0084) (CBMAB-E0178-FY)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0084
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0871) (V2LY-0825-LY241)

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Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0871
Application*: WB, E
Datasheet SDS

Rabbit Anti-ENO1 Recombinant Antibody (CBFYE-0870) (V2LY-0825-LY240)

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Target: ENO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0870
Application*: E
Datasheet SDS

ENO1 Matched Antibody Pair (378) (APMAB-378LY)

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Target: ENO1
Specificity: Human
Datasheet SDS

ENO1 Matched Antibody Pair (377) (APMAB-377LY)

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Target: ENO1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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