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ENO1

This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]
Full Name
Enolase 1
Research Area
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209).

In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581).

May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133).

Stimulates immunoglobulin production (PubMed:1369209).

MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Biological Process
Canonical glycolysis Source: UniProtKB
Glycolytic process Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: CAFA
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: CAFA
Positive regulation of ATP biosynthetic process Source: CAFA
Positive regulation of muscle contraction Source: CAFA
Positive regulation of plasminogen activation Source: CAFA
Regulation of vacuole fusion, non-autophagic Source: GO_Central
Response to virus Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm; M line. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
Isoform MBP-1: Nucleus
PTM
ISGylated.
Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity.

Anti-ENO1 antibodies

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Mouse Anti-ENO1 (AA 1-434) Recombinant Antibody (CBFYE-0874) (CBMAB-E1334-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-0874
Application*: WB, F, E, IF

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0872) (CBMAB-E1332-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-0872
Application*: WB

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0871) (CBMAB-E1331-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYE-0871
Application*: WB, P, IF

Rabbit Anti-ENO1 Recombinant Antibody (CBFYE-0870) (CBMAB-E1330-FY)

Datasheet SDS
Target: ENO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0870
Application*: E

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0869) (CBMAB-E1328-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0869
Application*: IP, F, IF, E

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0868) (CBMAB-E1326-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0868
Application*: IP, WB

Rabbit Anti-ENO1 Recombinant Antibody (CBFYE-0138) (CBMAB-E0301-FY)

Datasheet SDS
Target: ENO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBFYE-0138
Application*: WB, IP, IF

Mouse Anti-ENO1 Recombinant Antibody (CBFYE-0084) (CBMAB-E0178-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle, Frog
Clone: CBFYE-0084
Application*: WB, IF

Mouse Anti-ENO1 (AA 1-434) Recombinant Antibody (8G8) (CBMAB-E1329-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8G8
Application*: E, IF, P, IP, WB

Mouse Anti-ENO1 Recombinant Antibody (786CT6.6.4) (CBMAB-E1327-FY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse, Human
Clone: 786CT6.6.4
Application*: P, WB

Mouse Anti-ENO1 Recombinant Antibody (CBMAB-BR169LY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Horse, Human, Mouse, Pig, Rat
Application*: IF, IHC, WB

Rabbit Anti-ENO1 Recombinant Antibody (D2S1A) (CBMAB-CP0591-LY)

Datasheet SDS
Target: ENO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D2S1A
Application*: WB

Mouse Anti-ENO1 Recombinant Antibody (1G1) (CBMAB-A2610-LY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1G1
Application*: WB, E

Mouse Anti-ENO1 Recombinant Antibody (9E4) (CBMAB-A2609-LY)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 9E4
Application*: WB, E

Mouse Anti-ENO1 Recombinant Antibody (CBYC-A950) (CBMAB-A4388-YC)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A950
Application*: E, WB

Mouse Anti-ENO1 Recombinant Antibody (NSE-P1) (CBMAB-A4387-YC)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NSE-P1
Application*: C, E, P, WB

Mouse Anti-ENO1 Recombinant Antibody (9F7) (CBMAB-N0739-WJ)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 9F7
Application*: WB, IP

Mouse Anti-ENO1 Recombinant Antibody (3B10) (CBMAB-N0737-WJ)

Datasheet SDS
Target: ENO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B10
Application*: WB, IP

ENO1 Matched Antibody Pair (378) (APMAB-378LY)

Datasheet SDS
Target: ENO1
Specificity: Human

ENO1 Matched Antibody Pair (377) (APMAB-377LY)

Datasheet SDS
Target: ENO1
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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