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Fig.1 Melanoma

Melanoma, also named as malignant melanoma, is a type of cancer that originates from the pigment-containing cells called melanocytes. Melanomas normally occur in the skin but may occur in the eye, mouth or intestines sometimes. In women they most generally occur on the legs, while in men they are most common on the back. Sometimes they develop from a mole with concerning changes including an change in color, increase in size, itchiness, irregular edges or skin breakdown. The leading cause of melanoma is ultraviolet light (UV) exposure in those with low levels of skin pigment, may causing DNA damage. Melanoma is one of the most dangerous type of skin cancer. A diagnosis of melanoma is supported by the presence of the S-100 protein marker. HMB-45 is a monoclonal antibody that reacts with an antigen present in melanocytic tumors such as melanomas.