The prostate is a chestnut-shaped gland of the male reproductive that situated directly below the urinary bladder. The prostate surrounds the urethra and the two ejaculatory ducts which carry sperm and the fluid secreted by the seminal vesicles merges with the urethra in the center of the prostate. After running to the lower part of the prostate, the urethra exits near the apex. The structure of the prostate is composed of several distinct lobes (the two lateral lobes, anterior lobe, median lobe, posterior lobe). Exocrine glandular tissue and fibromuscular tissue are the primary tissue types of the prostate, which play an essential role in secreting and expelling the components of semen. The prostate reaches its mature size at puberty while it may become enlarged in size after midlife. The enlargement of the prostate has the potential to restrict or block the urethra, which may result in inflammation or malignancy. In addition, prostate cancer is also a common disorder in clinic. A variety of target molecules on prostate tissue are applied to detect the related diseases.