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FTH1

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Full Name
Ferritin Heavy Chain 1
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Biological Process
Cellular iron ion homeostasis Source: ProtInc
Immune response Source: UniProtKB
Intracellular sequestering of iron ion Source: UniProtKB
Iron ion transport Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of fibroblast proliferation Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Autolysosome; Nucleus; Cytoplasm; Ficolin-1-rich granule lumen; Intracellular ferritin complex; Tertiary granule lumen
Involvement in disease
The disease is caused by variants affecting the gene represented in this entry. In a Japanese family affected by HFE5, a single point mutation has been detected in the iron-responsive element (IRE) in the 5'-UTR of FTH1 mRNA. This mutation leads to an increased binding affinity for iron regulatory protein and thereby to the efficient suppression of mRNA translation. A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.

Anti-FTH1 antibodies

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Rabbit Anti-FTH1 Recombinant Antibody (D1D4) (CBMAB-CP0693-LY)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D1D4
Application*: WB, IP

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0944) (CBMAB-F0478-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0944
Application*: E

Mouse Anti-FTH1 Recombinant Antibody (CBXF-3880) (CBMAB-F0983-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3880
Application*: WB, E

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-1170) (CBMAB-F0984-CQ)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1170
Application*: WB, IC

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-1171) (CBMAB-F0985-CQ)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1171
Application*: WB, P

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-1152) (CBMAB-F0986-CQ)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBXF-1152
Application*: WB, P

Mouse Anti-FTH1 Recombinant Antibody (18B8) (CBMAB-F1034-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 18B8
Application*: WB

Mouse Anti-FTH1 Recombinant Antibody (F31) (CBMAB-F1335-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: F31
Application*: E

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0946) (CBMAB-F1458-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0946
Application*: WB, IC, P, C, E

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0947) (CBMAB-F1459-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-0947
Application*: WB, IC, P, C, E

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-2262) (CBMAB-F1898-CQ)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-2262
Application*: IF, WB

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-2083) (CBMAB-F2031-CQ)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXF-2083
Application*: WB, IP

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0945) (CBMAB-F2493-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0945
Application*: E

Mouse Anti-FTH1 Recombinant Antibody (CBXF-2683) (CBMAB-F3090-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2683
Application*: WB, IC

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0943) (CBMAB-F3216-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0943
Application*: E, P, WB

Mouse Anti-FTH1 Recombinant Antibody (CBXF-1896) (CBMAB-F3426-CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1896
Application*: E

Rabbit Anti-FTH1 Recombinant Antibody (BA0225) (CBMAB-0311CQ)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0225
Application*: C, P, WB

Mouse Anti-FTH1 Recombinant Antibody (3F8) (CBMAB-0312CQ)

Datasheet SDS
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: E, WB

Rabbit Anti-FTH1 Monoclonal Antibody (EPR18878) (CBMAB-1242-YC)

Datasheet SDS
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: EPR18878
Application*: P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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