FTH1

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Full Name
Ferritin Heavy Chain 1
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Biological Process
Cellular iron ion homeostasis Source: ProtInc
Immune response Source: UniProtKB
Intracellular sequestering of iron ion Source: UniProtKB
Iron ion transport Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of fibroblast proliferation Source: UniProtKB
Cellular Location
Cytosol; Extracellular exosome; Extracellular region; Autolysosome; Nucleus; Cytoplasm; Ficolin-1-rich granule lumen; Intracellular ferritin complex; Tertiary granule lumen
Involvement in disease
The disease is caused by variants affecting the gene represented in this entry. In a Japanese family affected by HFE5, a single point mutation has been detected in the iron-responsive element (IRE) in the 5'-UTR of FTH1 mRNA. This mutation leads to an increased binding affinity for iron regulatory protein and thereby to the efficient suppression of mRNA translation. A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
View more

Anti-FTH1 antibodies

+ Filters
Loading...

Rabbit Anti-FTH1 Recombinant Antibody (D1D4) (CBMAB-CP0693-LY)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D1D4
Application*: WB, IP
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-1896) (CBMAB-F3426-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1896
Application*: E
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (3F8) (CBMAB-0312CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F8
Application*: E, WB
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0947) (CBMAB-F1459-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-0947
Application*: WB, IC, P, C, E
Datasheet SDS

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-1152) (CBMAB-F0986-CQ)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBXF-1152
Application*: WB, P
Datasheet SDS

Rabbit Anti-FTH1 Recombinant Antibody (
39G3) (V2LY-0725-LY1262)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 39G3
Application*: E, WB, IF, F
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (
18C10) (V2LY-0725-LY714)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 18C10
Application*: E, WB, IH, F
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0943) (CBMAB-F3216-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0943
Application*: E, P, WB
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-2683) (CBMAB-F3090-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2683
Application*: WB, IC
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0945) (CBMAB-F2493-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0945
Application*: E
Datasheet SDS

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-2083) (CBMAB-F2031-CQ)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXF-2083
Application*: WB, IP
Datasheet SDS

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-2262) (CBMAB-F1898-CQ)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-2262
Application*: IF, WB
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0946) (CBMAB-F1458-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0946
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (F31) (CBMAB-F1335-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: F31
Application*: E
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (18B8) (CBMAB-F1034-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 18B8
Application*: WB
Datasheet SDS

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-1171) (CBMAB-F0985-CQ)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1171
Application*: WB, P
Datasheet SDS

Rabbit Anti-FTH1 Recombinant Antibody (CBXF-1170) (CBMAB-F0984-CQ)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1170
Application*: WB, IC
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-3880) (CBMAB-F0983-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3880
Application*: WB, E
Datasheet SDS

Mouse Anti-FTH1 Recombinant Antibody (CBXF-0944) (CBMAB-F0478-CQ)

Go to compareCompare
Target: FTH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0944
Application*: E
Datasheet SDS

Rabbit Anti-FTH1 Recombinant Antibody (BA0225) (CBMAB-0311CQ)

Go to compareCompare
Target: FTH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0225
Application*: C, P, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry
Happy Holidays
Happy Holidays close ad