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BMI1

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Full Name
BMI1 Proto-Oncogene, Polycomb Ring Finger
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373).
The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358).
In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Biological Process
Chromatin silencing Source: GO_Central
Hemopoiesis Source: UniProtKB
Histone H2A-K119 monoubiquitination Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of gene expression, epigenetic Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of fibroblast proliferation Source: BHF-UCL
Positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
Regulation of gene expression Source: BHF-UCL
Segment specification Source: ProtInc
Cellular Location
Nucleus; Cytoplasm
PTM
Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
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Anti-BMI1 antibodies

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Mouse Anti-BMI1 Recombinant Antibody (CBYC-P026) (CBMAB-P0108-YC)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Drosophila, Mouse
Clone: CBYC-P026
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-Bmi1 Recombinant Antibody (DC9) (CBMAB-CP0009-LY)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: DC9
Application*: WB
Datasheet SDS

Rabbit Anti-Bmi1 Recombinant Antibody (D42B3) (CBMAB-CP0008-LY)

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Target: BMI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D42B3
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-BMI1 Recombinant Antibody (4E10-1C5) (CBMAB-A6460-LY)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E10-1C5
Application*: WB, E
Datasheet SDS

Mouse Anti-BMI1 Recombinant Antibody (CBYY-1972) (CBMAB-2321-YY)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-1972
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-Bmi1 Recombinant Antibody (CBYY-1829) (CBMAB-2178-YY)

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Target: Bmi1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYY-1829
Application*: IF, IH, IC, WB, IP
Datasheet SDS

Mouse Anti-BMI1 Recombinant Antibody (CBYY-1686) (CBMAB-2035-YY)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: CBYY-1686
Application*: IH, WB, IP
Datasheet SDS

Rabbit Anti-BMI1 Recombinant Antibody (CBYY-0652) (CBMAB-0655-YY)

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Target: BMI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYY-0652
Application*: IH
Datasheet SDS

Rabbit Anti-BMI1 Recombinant Antibody (CBYY-0650) (CBMAB-0653-YY)

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Target: BMI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBYY-0650
Application*: IF, IH, IC, WB
Datasheet SDS

Mouse Anti-BMI1 Recombinant Antibody (CBYY-0645) (CBMAB-0648-YY)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-0645
Application*: IH
Datasheet SDS

Mouse Anti-BMI1 Recombinant Antibody (LLBmi1-1) (CBMAB-0163-YC)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: LLBmi1-1
Application*: IP, WB, IF, FC
Datasheet SDS

Mouse Anti-BMI1 Recombinant Antibody (CBT223) (V2LY-0625-LY3691)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT223
Application*: WB, P, IF, IC, F, E
Datasheet SDS

Mouse Anti-BMI1 Recombinant Antibody (CBT2235) (V2LY-0625-LY2644)

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Target: BMI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2235
Application*: IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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