BMI1
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
Full Name
BMI1 Proto-Oncogene, Polycomb Ring Finger
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373).
The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358).
In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358).
In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Biological Process
Chromatin silencing Source: GO_Central
Hemopoiesis Source: UniProtKB
Histone H2A-K119 monoubiquitination Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of gene expression, epigenetic Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of fibroblast proliferation Source: BHF-UCL
Positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
Regulation of gene expression Source: BHF-UCL
Segment specification Source: ProtInc
Hemopoiesis Source: UniProtKB
Histone H2A-K119 monoubiquitination Source: UniProtKB
Negative regulation of G0 to G1 transition Source: Reactome
Negative regulation of gene expression, epigenetic Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of fibroblast proliferation Source: BHF-UCL
Positive regulation of ubiquitin-protein transferase activity Source: UniProtKB
Regulation of gene expression Source: BHF-UCL
Segment specification Source: ProtInc
Cellular Location
Nucleus; Cytoplasm
PTM
Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
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Anti-BMI1 antibodies
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CompareTarget: BMI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Drosophila, Mouse
Clone: CBYC-P026
Application*: WB, IP, IF
Target: BMI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: DC9
Application*: WB
Target: BMI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D42B3
Application*: WB, IP, IF
Target: BMI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E10-1C5
Application*: WB, E
Target: BMI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-1972
Application*: WB, IP, IF, E
Target: Bmi1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYY-1829
Application*: IF, IH, IC, WB, IP
Target: BMI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: CBYY-1686
Application*: IH, WB, IP
Target: BMI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYY-0652
Application*: IH
Target: BMI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBYY-0650
Application*: IF, IH, IC, WB
Target: BMI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-0645
Application*: IH
Target: BMI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: LLBmi1-1
Application*: IP, WB, IF, FC
Target: BMI1
Sensitivity: 0.007 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Bmi1
Sensitivity: 0.022 ng/mL
Detection Range: 0.05-30 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: BMI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1F2
Application*: E, WB, IH
Target: BMI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT223
Application*: WB, P, IF, IC, F, E
Target: BMI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2235
Application*: IH, IC, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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